Thursday, February 28, 2013

Van Cliburn, American classical pianist, dies

FILE - This Sept. 18, 2008 file photo shows pianist Van Cliburn at the presentation ceremony of the Liberty Medal that was presented to former President of the Soviet Union Mikhail Gorbachev in Philadelphia. Cliburn, the internationally celebrated pianist whose triumph at a 1958 Moscow competition helped thaw the Cold War and launched a spectacular career that made him the rare classical musician to enjoy rock star status died early Wednesday, Feb. 27, 2013, at his Fort Worth home following a battle with bone cancer. (AP Photo/Tom Mihalek, file)

FILE - This Sept. 18, 2008 file photo shows pianist Van Cliburn at the presentation ceremony of the Liberty Medal that was presented to former President of the Soviet Union Mikhail Gorbachev in Philadelphia. Cliburn, the internationally celebrated pianist whose triumph at a 1958 Moscow competition helped thaw the Cold War and launched a spectacular career that made him the rare classical musician to enjoy rock star status died early Wednesday, Feb. 27, 2013, at his Fort Worth home following a battle with bone cancer. (AP Photo/Tom Mihalek, file)

FILE - This April 11, 1958 file photo shows pianist Van Cliburn performing in final round of Tchaikovsky International Piano & Violin competition in Moscow. Cliburn, the internationally celebrated pianist whose triumph at a 1958 Moscow competition helped thaw the Cold War and launched a spectacular career that made him the rare classical musician to enjoy rock star status died early Wednesday, Feb. 27, 2013, at his Fort Worth home following a battle with bone cancer. He was 78. (AP Photo, file)

FILE - This July 12, 2003 file photo shows pianist Van Cliburn after performing with the Boston Symphony Orchestra as the Orchestra plays "Happy Birthday," on his 69th birthday at Tanglewood in Lenox, Mass. Cliburn, the internationally celebrated pianist whose triumph at a 1958 Moscow competition helped thaw the Cold War and launched a spectacular career that made him the rare classical musician to enjoy rock star status died early Wednesday, Feb. 27, 2013, at his Fort Worth home following a battle with bone cancer. He was 78. (AP Photo/Michael Dwyer, file)

FILE - This Sept. 21, 2004 file photo shows pianist Van Cliburn performing during at a concert dedicated to the memory of the victims of the recent Beslan school massacre in Moscow. Cliburn, the internationally celebrated pianist whose triumph at a 1958 Moscow competition helped thaw the Cold War and launched a spectacular career that made him the rare classical musician to enjoy rock star status died early Wednesday, Feb. 27, 2013, at his Fort Worth home following a battle with bone cancer. He was 78. (AP Photo/Sergey Ponomarev, file)

FILE - This Feb. 19, 1959 file photo shows pianist Van Cliburn performing for the American Association of School Administrators at the Convention Hall in Atlantic, City, N.J. Cliburn, the internationally celebrated pianist whose triumph at a 1958 Moscow competition helped thaw the Cold War and launched a spectacular career that made him the rare classical musician to enjoy rock star status died early Wednesday, Feb. 27, 2013, at his Fort Worth home following a battle with bone cancer. He was 78. (AP Photo, file)

(AP) ? Van Cliburn, the internationally celebrated pianist whose triumph at a 1958 Moscow competition helped thaw the Cold War and launched a spectacular career that made him the rare classical musician to enjoy rock-star status, died Wednesday after a fight with bone cancer. He was 78.

Cliburn died at his home in Fort Worth surrounded by loved ones, said his publicist and longtime friend Mary Lou Falcone.

"Van Cliburn was an international legend for over five decades, a great humanitarian and a brilliant musician whose light will continue to shine through his extraordinary legacy," Falcone said in a statement. "He will be missed by all who knew and admired him, and by countless people he never met."

Cliburn made what would be his last public appearance in September at the 50th anniversary of the prestigious piano competition named for him. Speaking to the audience in Fort Worth, he saluted the many past contestants, the orchestra and the city. "Never forget: I love you all from the bottom of my heart, forever," he said to a roaring standing ovation.

Cliburn skyrocketed to fame when he won the first International Tchaikovsky Competition in Moscow at age 23 in 1958, six months after the Soviets' launch of Sputnik embarrassed the U.S. and propelled the world into the space age. He triumphantly returned to a New York City ticker tape parade ? the first ever for a classical musician ? and a Time magazine cover proclaimed him "The Texan Who Conquered Russia."

But the win also proved the power of the arts, bringing unity in the midst of strong rivalry. Despite the tension between the nations, Cliburn became a hero to music-loving Soviets who clamored to see him perform and Premier Nikita Khrushchev reportedly gave the go-ahead for the judges to honor a foreigner: "Is Cliburn the best? Then give him first prize."

In the years that followed, Cliburn's popularity soared, and the young man from the small east Texas town of Kilgore sold out concerts, caused riots when spotted in public and even prompted an Elvis Presley fan club to change its name to his. His recording of the Tchaikovsky Piano Concerto No. 1 with Russian conductor Kirill Kondrashin became the first classical album to reach platinum status.

Time magazine's 1958 cover story quoted a friend as saying Cliburn could become "the first man in history to be a Horowitz, Liberace and Presley all rolled into one."

Cliburn performed for royalty, heads of state in Europe, Asia and South America, and for every U.S. president since Harry Truman.

"Since we know that classical music is timeless and everlasting, it is precisely the eternal verities inherent in classical music that remain a spiritual beacon for people all over the world," Cliburn once said.

But he also used his skill and fame to help other young musicians through the Van Cliburn International Music Competition.

Created by a group of Fort Worth teachers and citizens in 1962, the competition, held every four years, remains a pre-eminent showcase for the world's top pianists. An amateur contest was added in 1999.

"It is a forum for young artists to celebrate the great works of the piano literature and an opportunity to expose their talents to a wide-ranging international audience," Cliburn said during the 10th competition in 1997. The 14th competition is to be held in May and June.

President George W. Bush presented Cliburn with the Presidential Medal of Freedom ? the nation's highest civilian honor ? in 2003. In 2004, he received the Order of Friendship of the Russian Federation from Russian President Vladimir Putin.

"I still have lots of friends in Russia," Cliburn said at the time. "It's always a great pleasure to talk to older people in Russia, to hear their anecdotes."

After the death of his father in 1974, Cliburn announced he would soon retire to spend more time with his ailing mother. He stopped touring in 1978.

He told The New York Times in 2008 that among other things, touring robbed him of the chance to enjoy opera and other musical performances. "I said to myself, 'Life is too short.' I was missing so much," he said. After winning the competition, he added, "it was thrilling to be wanted. But it was pressure too."

Cliburn emerged from his sabbatical in 1987, when he played at a state dinner at the White House during the historic visit to Washington of Soviet leader Mikhail Gorbachev. Gorbachev leapt from his seat to give the pianist a bear-hug and kisses on the cheeks.

The 13th Cliburn competition, held in 2009, made history when a blind pianist from Japan, Nobuyuki Tsujii, and a teenager from China, Haochen Zhang, both won gold medals. They were the first winners from any Asian country, and Tsujii was the first blind pianist to win. And it was only the second time there were dual first place winners.

Cliburn was born Harvey Lavan Cliburn Jr. on July 12, 1934, in Shreveport, La., the son of oilman Harvey Cliburn Sr. and Rildia Bee O'Bryan Cliburn. At age 3, he began studying piano with his mother, herself an accomplished pianist who had studied with a pupil of the great 19th century Hungarian pianist Franz Liszt.

The family moved back to Kilgore, Texas, within a few years of his birth.

Cliburn won his first Texas competition when he was 12, and two years later he played in Carnegie Hall as the winner of the National Music Festival Award.

At 17, Cliburn attended the Juilliard School in New York, where fellow students marveled at his marathon practice sessions that stretched until 3 a.m. He studied under the famed Russian-born pianist Rosina Lhevinne.

Between 1952 and 1958, he won all but one competition he entered, including the G.B. Dealey Award from the Dallas Symphony, the Kosciusko Foundation Chopin Scholarship and the prestigious Leventritt. By age 20, he had played with the New York Philharmonic and the symphonies of most major cities.

Cliburn's career seemed ready to take off until his name came up for the draft. Cliburn had to cancel all shows but was eventually excused from duty due to chronic nosebleeds.

Over the next few years, Cliburn's international popularity continued as he recorded pieces ranging from Mozart to a concerto by American Edward McDowell. Still, having been trained by arguably the best Russian teachers in the world, Cliburn's heart was Russian, with the Tchaikovsky and Rachmaninoff concertos.

After 1990, Cliburn toured Japan numerous times and performed throughout the United States. He was in the midst of a 16-city U.S. tour in 1994 when his mother died at age 97.

Cliburn made his home in Fort Worth, where in 1998 he appeared at the opening of the Nancy Lee and Perry R. Bass Performance Hall, both in recital and as soloist with the Fort Worth Symphony Orchestra. He endowed scholarships at many schools, including Juilliard, which gave him an honorary doctorate, and the Moscow and Leningrad Conservatories.

In December 2001, Cliburn was presented with the prestigious Kennedy Center Honors Medallion at the televised tribute held in Washington.

Until only recently, Cliburn practiced daily and performed limited engagements.

___

Online:

Van Cliburn Foundation: http://www.cliburn.org

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-02-27-Obit-Cliburn/id-77a55da8eebd470fb32236c3ba71931f

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BlackBerry takes another hit as Pentagon opens network to iPhone, Android phones

LOS ANGELES (Reuters) - Carrie Fisher, who played Princess Leia in the original "Star Wars" trilogy, was briefly hospitalized due to her bipolar disorder, the actress' spokeswoman said on Tuesday after video emerged of Fisher giving an unusual stage performance. The video came from a show Fisher gave aboard a cruise ship in the Caribbean last week, according to celebrity website TMZ, which posted the clip. The clip shows Fisher, 56, singing "Skylark" and "Bridge Over Troubled Waters," at times appearing to struggle to remember the lyrics. ...

Source: http://news.yahoo.com/blackberry-takes-another-hit-pentagon-opens-network-iphone-200031163.html

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Senate approves Lew as new Treasury chief

WASHINGTON (Reuters) - The U.S. Senate on Wednesday confirmed Jack Lew as President Barack Obama's new Treasury secretary, putting the former White House chief of staff in the middle of a bitter political fight over the government's budget.

Senators backed Lew with a 71-26 vote. All of the chamber's 53 Democrats voted for him. Some Republicans had expressed misgivings about Lew's perks from previous employers Citigroup and New York University.

Lew's most pressing task will be to find a compromise to lessen the economic blow from $85 billion in government spending cuts that are set to kick in on Friday.

But two more budget deadlines will quickly follow. Funds for most government operations expire on March 27, and the national debt will hit the U.S. government's borrowing limit on May 19, setting the stage for a default unless an agreement can be secured to raise the ceiling again.

Lew, who served as Obama's chief of staff before the president named him to succeed Timothy Geithner at the Treasury, has spent much of his career in Washington in public service.

He was previously White House budget director under both Obama and former President Bill Clinton.

By choosing him for the administration's top economic post, Obama signaled the importance he places on Washington's budget battles.

Now that he is confirmed, Lew is expected take the lead on difficult negotiations with Congress on how to trim U.S. budget deficits and keep a lid on $16.6 trillion U.S. national debt.

"If confirmed, we'll be entrusting Mr. Lew to oversee America's economic policy," said Senator Max Baucus, a Democrat who chairs the Finance Committee that vetted Lew for the job. "It is a great responsibility, one I believe Mr. Lew will live up to."

(Reporting by Anna Yukhananov and Rachelle Younglai; Editing by Mohammad Zargham)

Source: http://news.yahoo.com/senate-panel-backs-lew-treasury-secretary-013852659--sector.html

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Wednesday, February 27, 2013

Search called off for missing sailboat

SANTA CRUZ, Calif. (AP) ? The Coast Guard on Tuesday called off the search for a boat that reportedly sank in rough seas far off the Central California coast with two adults and two children on board, saying the family's frantic distress calls could have been a hoax.

Coast Guard Chief Petty Officer Mike Lutz said crews found no debris and no physical signs of distress after searching for nearly 48 hours.

Crews have been looking for the family by sea and air since receiving their first distress call Sunday afternoon.

The boaters said their 29-foot sailboat, which might have been called "Charmblow," was taking on water and their electronics were failing.

The boat had no working GPS system, but investigators used its radio signal and radar to determine the call came from an area about 60 miles west of Monterey, where strong winds, cold water and big swells made for perilous conditions. Forecasters had issued a weekend advisory warning boaters of high swells in the area.

An hour later, the family members reported they had to abandon the boat and were trying to make a life raft out of a cooler and life-preserver ring. The Coast Guard then lost radio contact.

Investigators determined from the broken distress calls that the family included a husband and wife, their 4-year-old son and his cousin, Coast Guard Lt. Heather Lampert said. The agency received no reports about a family missing at sea.

On Monday, the Coast Guard released one of the recorded calls in hopes that it would lead to new information from the public that could help in the search.

In the crackling recording, a man's voice is heard saying, "Coast Guard, Coast Guard, we are abandoning ship. This is the (Charmblow), we are abandoning ship."

Lutz said earlier Tuesday there was nothing on the distress call such as laughter that would spark suspicion, and he did not think it was particularly unusual that the man on the call sounded calm.

"You never really know how someone is going to handle it," Lutz said. "Some people are a lot calmer than others."

Coast Guard Executive Officer Noah Hudson in Monterey said it's always difficult to call off a search.

"It's tough for me thinking that we had four people out on the water who were in need of rescue and to think there might have been loss of life in this case is tragic."

But if it was a hoax, "it's unfortunate that we were forced to use so many resources for so much time," Hudson said. He did not know how much money had been spent on the search efforts.

Source: http://news.yahoo.com/search-called-off-boat-reportedly-sank-191005619.html

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Was that Peter Brady hosting the Oscars?

By Gael Fashingbauer Cooper, TODAY

One's a "Family Guy," the other wanted to "somehow form a family." Oscar-watchers were of differing opinions on host Seth MacFarlane's performance at Sunday's big awards show, but many found one thing to agree on: He looked an awful lot like Peter Brady.

TODAY

Here's the story: Some Oscar-watchers felt host Seth MacFarlane looked more than a little like Peter Brady.

Twitter users spotted the comparison early, and began sharing photo comparisons and of course, "Brady" references.

?

You remember Peter, the Brady family's middle son, played by actor Christopher Knight. Peter loved movies too -- he famously once tried to say "pork chops and applesauce" in the style of Humphrey Bogart. And he was more than a little into drama, once getting big brother Greg to attempt a "Cyrano" act with him in hopes of charming a girl, and pretending to his parents that he was still employed after a bike shop fired him for working too slow.

MacFarlane acknowledges the resemblance, telling Parade magazine on Sunday, "I get a lot of 'Hey, aren't you Peter Brady?'" And maybe the resemblance is more than skin-deep.

If you'll remember, poor Peter, like middle sister Jan, had it a little rough. He never pulled off the suave charm of Greg or the little-kid cuteness of little Bobby.?Maybe, as the mixed reviews of MacFarlane's hosting gig continue to trickle in, the comic can relate.

Source: http://todayentertainment.today.com/_news/2013/02/25/17087872-peter-brady-is-that-you-heres-the-story-of-oscar-host-resemblance?lite

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Tuesday, February 26, 2013

10 Things to Know for Today

A man casts his vote for the Italian Senate, in Piacenza, Italy, Sunday, Feb. 24, 2013. Italy votes in a watershed parliamentary election Sunday and Monday that could shape the future of one of Europe's biggest economies. (AP Photo/Marco Vasini)

A man casts his vote for the Italian Senate, in Piacenza, Italy, Sunday, Feb. 24, 2013. Italy votes in a watershed parliamentary election Sunday and Monday that could shape the future of one of Europe's biggest economies. (AP Photo/Marco Vasini)

From left, Grant Heslov and Ben Affleck hold their awards for best picture for "Argo" backstage at the Oscars at the Dolby Theatre on Sunday Feb. 24, 2013, in Los Angeles. (Photo by Matt Sayles/Invision/AP)

Cuba's President Raul Castro, waves after voting during a session of the National Assembly in Havana, Cuba, Sunday, Feb. 24, 2012. Cuba?s President Raul Castro accepted a new five-year term that will be, he said, his last as Cuba's president and tapped rising star Miguel Diaz-Canel, 52, as vice-president and first in the line of succession. Diaz-Canel has risen higher than any other Cuban official who didn't directly participate in the 1959 Cuban revolution. (AP Photo/Ismael Francisco, Cubadebate)

Your daily look at late-breaking news, upcoming events and the stories that will be talked about today:

1. 'ARGO,' 'LIFE OF PI' BIG OSCAR WINNERS

Ben Affleck's CIA thriller won best picture, while "Life of Pi" won four trophies, including best director for Ang Lee.

2. STATE-BY-STATE FALLOUT FROM BUDGET CUTS

The White House detailed the impact from $85 billion in cuts set to take effect at week's end.

3. A DATE FOR END OF CASTRO ERA

Raul Castro says he will step down as Cuba's president in 2018.

4. ASSIGNING BLAME FOR GULF OIL SPILL

A trial begins today to determine how much in damages oil giant BP and other companies should pay for the 2010 disaster.

5. HORSE MEAT SCANDAL HITS IKEA

Furniture retailer pulls its Swedish meatballs from shelves in Britain, Ireland and several European countries after Czech authorities detect horse meat in packages labeled as being made of pork and beef.

6. POPE BENEDICT CHANGES THE RULES

In one of his last acts as pope, the pontiff signs the document allowing for an earlier start to the conclave that will elect his successor.

7. ANOTHER STORM HEADED TO CENTRAL US

Blizzard warnings were in effect in Kansas after up to a foot and a half of snow fell there last week.

8. SETH MACFARLANE PRAISED AS IRREVERENT OSCAR HOST

"Macfarlane's strategic misbehavior furnished welcome relief," AP Television Writer Frazier Moore says.

9. TRIPS AND FALLS AT THE OSCARS

Best Actress winner Jennifer Lawrence stumbled on her way to the podium, and injured presenter Kristen Stewart hobbled onstage.

10. POUR ON THE OLIVE OIL

A five-year study finds people who ate Mediterranean-style diets had a 30 percent lower risk of cardiovascular problems.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-02-25-10%20Things%20to%20Know-Today/id-a576d55d4b334be2bec09d7e1d3c350c

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Future evidence for extraterrestrial life might come from dying stars

Feb. 25, 2013 ? Even dying stars could host planets with life -- and if such life exists, we might be able to detect it within the next decade. This encouraging result comes from a new theoretical study of Earth-like planets orbiting white dwarf stars. Researchers found that we could detect oxygen in the atmosphere of a white dwarf's planet much more easily than for an Earth-like planet orbiting a Sun-like star.

"In the quest for extraterrestrial biological signatures, the first stars we study should be white dwarfs," said Avi Loeb, theorist at the Harvard-Smithsonian Center for Astrophysics (CfA) and director of the Institute for Theory and Computation.

When a star like the Sun dies, it puffs off its outer layers, leaving behind a hot core called a white dwarf. A typical white dwarf is about the size of Earth. It slowly cools and fades over time, but it can retain heat long enough to warm a nearby world for billions of years.

Since a white dwarf is much smaller and fainter than the Sun, a planet would have to be much closer in to be habitable with liquid water on its surface. A habitable planet would circle the white dwarf once every 10 hours at a distance of about a million miles.

Before a star becomes a white dwarf it swells into a red giant, engulfing and destroying any nearby planets. Therefore, a planet would have to arrive in the habitable zone after the star evolved into a white dwarf. A planet could form from leftover dust and gas (making it a second-generation world), or migrate inward from a larger distance.

If planets exist in the habitable zones of white dwarfs, we would need to find them before we could study them. The abundance of heavy elements on the surface of white dwarfs suggests that a significant fraction of them have rocky planets. Loeb and his colleague Dan Maoz (Tel Aviv University) estimate that a survey of the 500 closest white dwarfs could spot one or more habitable Earths.

The best method for finding such planets is a transit search -- looking for a star that dims as an orbiting planet crosses in front of it. Since a white dwarf is about the same size as Earth, an Earth-sized planet would block a large fraction of its light and create an obvious signal.

More importantly, we can only study the atmospheres of transiting planets. When the white dwarf's light shines through the ring of air that surrounds the planet's silhouetted disk, the atmosphere absorbs some starlight. This leaves chemical fingerprints showing whether that air contains water vapor, or even signatures of life, such as oxygen.

Astronomers are particularly interested in finding oxygen because the oxygen in Earth's atmosphere is continuously replenished, through photosynthesis, by plant life. Were all life to cease on Earth, our atmosphere would quickly become devoid of oxygen, which would dissolve in the oceans and oxidize the surface. Thus, the presence of large quantities of oxygen in the atmosphere of a distant planet would signal the likely presence of life there.

NASA's James Webb Space Telescope (JWST), scheduled for launch by the end of this decade, promises to sniff out the gases of these alien worlds. Loeb and Maoz created a synthetic spectrum, replicating what JWST would see if it examined a habitable planet orbiting a white dwarf. They found that both oxygen and water vapor would be detectable with only a few hours of total observation time.

"JWST offers the best hope of finding an inhabited planet in the near future," said Maoz.

Recent research by CfA astronomers Courtney Dressing and David Charbonneau showed that the closest habitable planet is likely to orbit a red dwarf star (a cool, low-mass star undergoing nuclear fusion). Since a red dwarf, although smaller and fainter than the Sun, is much larger and brighter than a white dwarf, its glare would overwhelm the faint signal from an orbiting planet's atmosphere. JWST would have to observe hundreds of hours of transits to have any hope of analyzing the atmosphere's composition.

"Although the closest habitable planet might orbit a red dwarf star, the closest one we can easily prove to be life-bearing might orbit a white dwarf," said Loeb.

Their paper has been accepted for publication in the Monthly Notices of the Royal Astronomical Society.

Headquartered in Cambridge, Mass., the Harvard-Smithsonian Center for Astrophysics (CfA) is a joint collaboration between the Smithsonian Astrophysical Observatory and the Harvard College Observatory. CfA scientists, organized into six research divisions, study the origin, evolution and ultimate fate of the universe.

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Story Source:

The above story is reprinted from materials provided by Harvard-Smithsonian Center for Astrophysics.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Abraham Loeb, Dan Maoz. Detecting bio-markers in habitable-zone earths transiting white dwarfs. Arxiv, 2013 [link]

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/N7HMdoJEg3U/130225131618.htm

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Columbia Business School Dean Glenn Hubbard's Outside ...

Yesterday we showed you the "outside compensation" list of Columbia's Fred Mishkin.

Today, it's the turn of Columbia Business School dean and Mitt Romney's "go to economist", Glenn "You have three more minutes, give it your best shot" Hubbard. Here they are:

Consulting or Speaking Engagements at Some Point During the Past Five Years: U.S. Department of Justice, Airgas, Alternative Investment Group, American Century, America?s Health Insurance Plans, ApexBrasil, Association for Corporate Growth, Bank of America, Bank of New York Mellon, Barclays Services Corporation, BNP Paribas, Capital Research, Citigroup, Deutsche Bank, Fidelity, Franklin Resources, Freddie Mac, Goldman Sachs, Intel, JP Morgan Chase, Microsoft, National Rural Utilities Cooperative Finance Corporation, NMS Group, Oracle, Pension Real Estate Association, Real Estate Roundtable, Reynolds American, Royal Bank of Scotland, Visa, Wells Fargo, Nomura Holdings America, Laurus Funds, Ripplewood Holdings

And as a reminder:

Source: Glenn Hubbard resume

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Source: http://www.zerohedge.com/news/2013-02-24/columbia-business-school-dean-glenn-hubbards-outside-consulting-and-advisory-relatio

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iMore show. Tonight. 6pm PT. 9pm ET. Be here!

iMore show. Tonight. 6pm PT. 9pm ET. Be here!

Forget the Walking Dead (or whatever they call the Oscars these days...) because the iMore show is coming your way LIVE tonight. David Chartier is joining us, and we'll be talking about Google's new hardware and what, if anything, it means for iOS and Apple users. We'll also be talking about default apps on iPhone and iPad, and a whole lot more. You don't want to miss it.

6pm PT, 9pm ET. Be here.



Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/3VP2PPpqvIU/story01.htm

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Monday, February 25, 2013

Jennifer Lawrence Hot or Not At 2013 Film Independent Spirit Awards

Jennifer Lawrence arrived at the 2013 Film Independent Spirit Awards wearing a super hot (or not) Lanvin dress. Check it out, what do you think? PR Photos On one hand she looks amazing, and maybe it is just the angle in my photo agency’s gallery, but in some she looks horrible. Jennifer showed some sideboob and a lot of skin in the backless Lanvin design, which also featured a metal, choker collar, bow at the waste, and asymmetrical skirt. Sometimes she looks like Katniss others, just an awkward girl not sure if this was the right option. I love the girl don’;t get me wrong, but I don’t think this was the best choice for her. What do you think is Jennifer hot or not? Sound off in the comments.

Source: http://feedproxy.google.com/~r/RightCelebrity/~3/yURYQORC-iE/

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All condemn pending budget cuts, spread blame

WASHINGTON (AP) ? The White House and Republicans kept up the unrelenting mudslinging Sunday over who's to blame for roundly condemned budget cuts set to take effect at week's end, with the administration detailing the potential fallout in each state and governors worrying about the mess.

But as leaders rushed past each other to decry the potentially devastating and seemingly inevitable cuts, they also criticized their counterparts for their roles in introducing, implementing and obstructing the $85 billion budget mechanism that could affect everything from commercial flights to classrooms to meat inspections. The GOP's leading line of criticism hinged on blaming President Barack Obama's aides for introducing the budget trigger in the first place, while the administration's allies were determined to illustrate the consequences of the cuts as the product of Republican stubbornness.

Former Republican National Committee chairman Haley Barbour, aware the political outcome may be predicated on who is to blame, half-jokingly said Sunday, "Well, if it was a bad idea, it was the president's idea."

Sen. Claire McCaskill, D-Mo., said there was little hope to dodge the cuts "unless the Republicans are willing to compromise and do a balanced approach."

No so fast, Republicans interjected.

"I think the American people are tired of the blame game," said Sen. Kelly Ayotte, R-N.H.

Yet just a moment before, she was blaming Obama for putting the country on the brink of massive spending cuts that were initially designed to be so unacceptable that Congress would strike a grand bargain to avoid them.

Obama nodded to the squabble during his weekly radio and Internet address.

"Unfortunately, it appears that Republicans in Congress have decided that instead of compromising ? instead of asking anything of the wealthiest Americans ? they would rather let these cuts fall squarely on the middle class," Obama said Saturday, in his last weekly address before the deadline.

"We just need Republicans in Washington to come around," Obama added. "Because we need their help to finish the job of reducing our deficit in a smart way that doesn't hurt our economy or our people."

With Friday's deadline nearing, few in the nation's capital were optimistic that a realistic alternative could be found and all sought to cast the political process itself as the culprit. If Congress does not step in, a top-to-bottom series of cuts will be spread across domestic and defense agencies in a way that would fundamentally change how government serves its people.

Obama senior adviser Dan Pfeiffer told reporters the GOP is "so focused on not giving the president another win" that they will cost thousands of jobs. To back up their point, the White House released state-by-state tallies for how many dollars and jobs the budget cuts would mean to each state.

"The Republicans are making a policy choice that these cuts are better than eliminating loopholes," Pfeiffer said.

And, yes, those cuts will hurt. They would slash from domestic and defense spending alike, leading to furloughs for hundreds of thousands of government workers and contractors.

Defense Secretary Leon Panetta has said the cuts would harm the readiness of U.S. fighting forces. Transportation Secretary Ray LaHood said travelers could see delayed flights. Education Secretary Arne Duncan said 70,000 fewer children from low-income families would have access to Head Start programs. And furloughed meat inspectors could leave plants idled.

In Virginia, for instance, 90,000 Defense Department civilian employees could be furloughed, including nurses at Army hospitals, said Sen. Tim Kaine, D-Va. He also said ship-repair contractors could lay off 300 of their 450 employees.

"There is no reason that this has to happen. We just need to find a balanced approach," Kaine said.

White House officials also pointed to Ohio as another state that would be hit hard: $25.1 million in education spending and another $22 million for students with disabilities. Some 2,500 children from low-income families would also be removed from Head Start programs.

Officials said their analysis showed Kentucky would lose $93,000 in federal funding for a domestic abuse program, meaning 400 fewer victims being served in Senate Minority Leader Mitch McConnell's home state. Georgia, meanwhile, would face a $286,000 budget cut to its children's health programs, meaning almost 4,200 fewer children would receive vaccinations against measles and whooping cough.

White House officials said Nevada would face military furloughs totaling $12.1 million in reduced pay, a $424,000 cut to pay for meals for seniors and an almost $2 million reduction for clean air and water programs.

The White House compiled the state-by-state reports from federal agencies and its own budget office. The numbers reflect the impact of the cuts this year. Unless Congress acts by Friday, $85 billion in cuts are set to take effect from March to September.

As to whether states could move money around to cover shortfalls, the White House said that depends on state budget structures and the specific programs. The White House did not have a list of which states or programs might have flexibility.

Republican leaders were not impressed by the reports for the 50 states and the District of Columbia.

"The White House needs to spend less time explaining to the press how bad the sequester will be and more time actually working to stop it," said Michael Steel, a spokesman for House Speaker John Boehner of Ohio.

Some governors said the impasse was just the latest crisis in Washington that is keeping businesses from hiring and undermining the ability of state leaders to develop their own spending plans.

"It's senseless and it doesn't need to happen," said Gov. Martin O'Malley, D-Md., during the annual meeting of the National Governors Association over the weekend.

"And it's a damn shame, because we've actually had the fastest rate of jobs recovery of any state in our region. And this really threatens to hurt a lot of families in our state and kind of flat-line our job growth for the next several months," O'Malley said.

Obama did not mention the budget cuts in remarks before his dinner with the governors Sunday evening at the White House; he is expected to address the issue in a speech Monday morning to the same group. But time is running out and hope is waning.

Connecticut Gov. Dan Malloy said it is past time for both sides to sit down to help dodge cuts that will hurt all states' budgets.

"Come to the table, everyone. Everybody. Let's work this thing out. Let's be adults," said Malloy, a Democrat.

Sen. John McCain, R-Ariz., called the defense cuts "unconscionable" and urged Obama to call lawmakers to the White House or the presidential retreat of Camp David for a last-minute budget summit.

"I won't put all the blame all on the president of the United States. But the president leads. The president should be calling us over somewhere ? Camp David, the White House, somewhere ? and us sitting down and trying to avert these cuts," McCain said.

LaHood, who served as a Republican representing Illinois in the U.S. House, urged his colleagues to watch Steven Spielberg's film about President Abraham Lincoln's political skills.

"Everybody around here ought to go take a look at the 'Lincoln' movie, where they did very hard things by working together, talking together and compromising," said LaHood. "That's what's needed here."

LaHood and Duncan were the only representatives from the administration to appear on Sunday shows. The White House did not book any of its senior aides.

Barbour, Malloy and McCain appeared on CNN's "State of the Union." McCaskill was interviewed on "Fox News Sunday." Ayotte, Duncan and Kaine spoke with CBS' "Face the Nation." LaHood appeared on both CNN and NBC.

___

Follow Philip Elliott on Twitter: https://twitter.com/philip_elliott

Source: http://news.yahoo.com/condemn-pending-budget-cuts-spread-blame-211746860--finance.html

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Sunday, February 24, 2013

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Is the Muslim Brotherhood seeking to kill Egypt's NGOs?

A restrictive draft law sponsored by a member of the Muslim Brotherhood's party echoes the philosophy of the Mubarak government, which saw independent groups as a threat.

By Kristen Chick,?Correspondent / February 22, 2013

A demonstrator, who supports the Muslim Brotherhood, waves an Egyptian national flag as he chants slogans in support of Egypt's President Mohamed Morsi in Cairo, Feb. 15. Last week, a member of the Muslim Brotherhood's Freedom and Justice Party's (FJP) proposed a new draft law that echoes the philosophy of the Mubarak government.

Mohamed Abd El Ghany/Reuters

Enlarge

A government minister and member of the Muslim Brotherhood's Freedom and Justice Party (FJP) has proposed a highly restrictive law that rights activists say would cripple civil society groups in Egypt and mark an alarming shift by the Brotherhood toward the methods of the ousted Hosni Mubarak.

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The draft law is likely to be revised before it is sent to Egypt's legislative body for approval. Even so, nongovernmental organization (NGO) leaders and activists say the draft shows that the FJP is adopting the philosophy of former President Mubarak, whose government saw independent groups as a threat and sought to restrict their actions and funding.

Last year, before the FJP's Mohamed Morsi was elected president, the party proposed a law that earned cautious praise from rights organizations. Last week, Mohamed Ali Bishr, a prominent Muslim Brotherhood and FJP member and minister of local development, proposed a new draft that is closer to the highly restrictive bill proposed by another government ministry.

It would interfere in the details of how NGOs operate and organize, and would tightly restrict the foreign funding that rights organizations in Egypt rely on. For the first time in history it would give a legal role to Egypt's security apparatus in overseeing civil society organizations.

If a law much like the current draft passes, ?NGOs will not work actively. They will work under the pressure of the law and the government; they will not be healthy NGOs. There's no hope for those that work in human rights or criticize the government on human rights to obtain foreign funding,? says Mohamed Zaree, Egypt program manager at the Cairo Institute for Human Rights Studies (CIHRS).

Mubarak's time

Mubarak's government saw civil society organizations, particularly those focused on human rights, as a threat. Most rely on funding from abroad, and he sought to restrict or control that funding. When Mubarak was ousted by a popular uprising in 2011, the military stepped in to rule Egypt, but the officials responsible for regulating civil society remained. They launched a crackdown on NGOs that were foreign or received foreign funding, raiding offices, confiscating cash and equipment, and investigating employees.

They eventually brought charges against 43 people, including Americans, accusing them of receiving foreign funds illegally. In public statements leading up to the trial, officials implied those charged had been working to destabilize Egypt. Most of the Americans fled the country last year, but one remained to face the charges.

When the FJP proposed a draft NGO law last year, the military was still ruling Egypt. In at least one article of that draft law, the Brotherhood's party took almost word for word the recommendations made by CIHRS and other rights organizations. Rights activists say the law did have portions they considered problematic, but on the whole it was progressive. They were startled to see the FJP's new draft revert to the vision outlined by the Ministry of Insurance and Social Affairs, which has advanced the Mubarak-era approach toward NGOs.

Amnesty International said yesterday that the Ministry of Insurance and Social Affairs recently sent a letter to the Egyptian Organization for Human Rights saying that local organizations are not allowed toengage with ?international entities? in any way without the permission of the ?security bodies, " apparently on the instructions of the prime minister.?

The first draft law ?was introduced by the Muslim Brotherhood in different political circumstances,? says Bahey el Din Hassan, head of CIHRS, noting that a military junta was then ruling Egypt. Now, with Morsi as president and the FJP dominating the only legislative body currently active, ?they have everything. So why would they make concessions to civil society? This is what changed."

Mr. Zaree says the draft law was presented in a meeting at the Justice Ministry attended by CIHRS as the FJP's proposal. FJP spokesman Mourad Ali would only say that the draft law is still being discussed and is not finalized. He declined to answer further questions, as did other FJP members.

An official at the presidency, who asked not to be named, said "the presidency is keen on building consensus on the associations law. No NGOs law has been submitted to the Shura Council [Egypt's legislative body] yet. We have urged the cabinet to withhold submitting a draft law until a more consensual version is in place."

Damage done

Heba Morayef, Egypt director for Human Rights Watch, says the damage is done when those writing the law start with such a repressive draft, even if they promise revisions. ?The problem is that once you adopt language that is very restrictive, even when you attempt to revise it, the revisions tend to be limited,? she says. ?The first draft is very significant.?

The FJP draft law calls for foreign funding to be tightly restricted. It requires organizations to receive prior approval from a government minister before they can receive funds, and the minister doesn't have to justify a decision to say no. Already, under the current law, authorities are rejecting or holding up many organization's applications for approval to receive funds from abroad, says Zaree.

Mr. Hassan says the ministerial veto could be used against organizations the government sees as a nuisance ? for example, those working to document torture or abuse by security forces.

The most worrying article for many in NGOs is one that designates all NGO funds except member dues as ?public funds.? Zaree, Egypt program manager at CIHRS, says it takes the ?non? out of ?nongovernmental organizations? and ?nationalizes? civil society. That designation would give the government greater oversight and allow it greater interference in NGO work ? including allowing several government entities the right to review the activities and finances of NGOs at any time, says Zaree.

?This gives you a sense that they look at civil society as a branch of the government. It's not independent,? he says.

Next stop: Jail

Hassan says the law means ministry officials can come to an NGO's offices at any time, review anything they want ? related to activities or finances ? and refer the employees on the spot to the prosecutor.

The law would also set up a committee to approve the registration of international NGOs. That committee can reject the registration request of any organization if it decides that Egyptian society is not in need of its work ? for example, if the committee members decide there is no need for investigating torture or raising political awareness. ?It's a very very broad criteria,? says Zaree.

International NGOs that receive foreign government funding, either directly or indirectly, would not be allowed to work in Egypt. That would immediately disqualify many organizations, including the International Republican Institute and the National Democratic Institute, both American organizations targeted in the NGO crackdown. They are affiliated with the Republican and Democratic parties in the US, and receive most of their budget from the government's National Endowment for Democracy.

For local NGOs, the law interferes in minor details of how they organize themselves. Those that receive foreign funding would be required to submit a quarterly report on their activities and finances to the government. That puts an unreasonable burden on NGOs, who would spend most of their time writing those reports instead of working, says Zaree. And the law mandates prison sentences, instead of fines, for those who break the law.

Rights advocates say the regulations in the law would effectively prohibit many international NGOs from working in Egypt, and greatly hinder or stop the work of local NGOs as well. Asked if CIHRS could operate under the draft law, if it were implemented, Hassan said, ?if it was passed like this, I don't think it would be possible. If we didn't shut down they would come and shut us down.?

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/QIRFSmmtdOo/Is-the-Muslim-Brotherhood-seeking-to-kill-Egypt-s-NGOs

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Convert Sony PMW-350(PMW-350K, PMW-350L) MP4 for Premiere Pro on Mac

Convert Sony PMW-350(PMW-350K, PMW-350L) MP4 for Premiere Pro on Mac

Summary:Follow this article, you can solve your Sony PMW-350, 350K, 350L MP4 files to Adobe Premiere Pro CS6/CS5/CS4 importing issue, please read.

Sony continues to expand and improve its XDCAM EX lineup with the PMW-350(PMW-350K, PMW-350L) Full HD Camcorder. Boasting three 2/3"-type full-HD CMOS sensors, solid state SxS workflow and an impressive set of advanced features, this professional shoulder-mount camera sets a new standard for affordable, high-end videography. With a chassis based on the XDCAM HD422, the PMW-350K also manages to be one of the lightest--and most well-balanced--camcorders in its class.

PMW-350(PMW-350K, PMW-350L) Recording codec:

1920 x 1080 HD Recording Using the "MPEG-2 Long GOP" Codec

The PMW-350 records 1920 x 1080 full HD images using the "MPEG-2 Long GOP" codec, which conforms to the MPEG-2 MP@HL compression standard. "MPEG-2 Long GOP" is a mature codec--also adopted by the XDCAM HD and HDV 1080i series of products--which enables users to record stunning HD video and audio with highly efficient, reliable data compression.

"MP4" friendly format:

With the XDCAM EX series, recordings are made as data files in the "MP4" format, which is widely used in a number of recent electronic portable devices and has been standardized by ISO.

The file-based recording allows material to be handled with great flexibility in an IT-based environment--easily available for copying, transferring, sharing, and archiving. All these operations are accomplished without any "digitizing" process required.

How to transfer Sony PMW-350/350K/350L MP4 files to Adobe Premiere Pro CS6/CS5/CS4 for editing on Mac?

The best video codec and format supported by Adobe Premiere Pro CS6/CS5/CS4 on Mac is:Apple ProRes 422 codec MOV format, or QuickTime MOV format.

So before importing Sony PMW-350/350K/350L MP4 files to Adobe Premiere Pro CS6/CS5/CS4, you can use Pavtube HD Video Converter for Mac to transcode Sony PMW-350/350K/350L MP4 to MOV for Premiere Pro CS6/CS5/CS4, and then you can edit smoothly. Now please follow the steps below to know detail conversion steps.

1. Download and install Pavtube HD Video Converter for Mac. It?s an excellent software which can convert Sony PMW-350/350K/350L MP4 to MOV for Adobe Premiere Pro CS6/CS5/CS4 on Mac 10.8, more output formats are also supported, such as MOV, AVI, etc.

2. Import the Sony PMW-350/350K/350L MP4 video you want to convert.

3. Click format column to choose the best video format for editing in Adobe Premiere Pro CS6/CS5/CS4 on Mac. Click and choose Apple ProRes 422 MOV for output. You can also choose Adobe Premiere -> MOV for output.

4. You can customize output parameters as you want. Adjust the resolution, bitrate, etc according to your need; you can also keep the parameters as original.

5. After these steps above, click convert button to start converting Sony PMW-350/350K/350L MP4 to ProRes MOV for Adobe Premiere Pro CS6/CS5/CS4 on Mac.

As soon as the conversion process finished, you can click ?Open? button to get the generated file that is ready for editing with Premiere Pro.

* Start up Premiere Pro, choose File > Import?, and navigate to the source folder to import files.

This Sony PMW MP4 to Premiere Pro converter will help you convert videos with best quality, and then you can edit Sony PMW-350/350K/350L MP4 in Adobe Premiere Pro CS6/CS5/CS4 on Mac as you want with no codec problems.

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Source: http://forums.coolest-gadgets.com/showthread.php?t=56963&goto=newpost

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Saturday, February 23, 2013

eBay: Asus Google Nexus 7 ASUS-1B32 32GB Tablet + $30 Visa GC + Ear Buds bundle $259 shipped

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The Note's Must-Reads for Friday February 22, 2013

The Note's Must-Reads are a round-up of today's political headlines and stories from ABC News and the top U.S. newspapers. Posted Monday through Friday right here at www.abcnews.com

Compiled by ABC News' Carrie Halperin, Jayce Henderson and Will Cantine

FISCAL BATTTLE ABC News' Chris Good: " 57 Terrible Consequences Of The Sequester" If the heads of 20 federal agencies are to be believed, disastrous consequences await if President Obama and Congress fail to reach a budget deal, triggering the automatic, across-the-board cuts known as "sequestration." The cuts are slated to begin March 1, and earlier this month, the Senate Appropriations Committee asked agency heads to explain what would happen in such a scenario. LINK

USA Today's David Jackson: " Obama Speaks To GOP Leaders Amid Sequester Campaign" President Obama took some time off from his sequester campaign Thursday to speak with his top two Republican rivals in Congress, House Speaker John Boehner and Senate Minority Leader Mitch McConnell. Obama and GOP aides had little to say about the conversations. The White House announced that Obama would travel to Virginia next week to discuss what effects automatic budget cuts would have on the defense industry. LINK

The Wall Street Journal's Sudeep Reddy: " Sudden Spending Cuts Likely To Bleed Slowly" The political jousting over the federal spending cuts set to start March 1 largely comes down to how much of an economic blow they could deal. But it may take a while to assess whether it feels more like a punch or a pinch, because the reductions will take effect over many months. LINK

The New York Times' Jeff Zeleny and Jonathan Weisman: " For Obama and Team, Calm, Not Crisis, in Latest Fiscal Battle" President Obama is just seven days away from the first significant test of his second term as deep spending cuts loom, yet inside the White House a clear sense of confidence stands in contrast to the air of crisis that surrounded previous fiscal showdowns with Republicans. The confrontation holds peril for both the president and Republicans. But for now, Mr. Obama believes he is acting from a greater position of strength, advisers say, pointing to several recent polls that show he holds an upper hand in the budget debate. Yet his standing would be at risk if the so-called sequester caused economic growth to collapse. LINK

The Washington Post's Ernesto Londono and Lisa Rein: " Military service chiefs warn budget cuts will undermine readiness" After staying largely on the sidelines of the debate over deficit reduction, the U.S. military's service leaders have begun painting a stark picture of the toll a congressionally mandated budget cut could take on the readiness of the world's largest armed forces. The $46 billion dent to the Pentagon's fiscal 2013 budget, long considered by the brass as nothing more than a political pawn, has taken on an air of inevitability, forcing commanders across the military to plan for painful reductions and argue that American lives and livelihoods are hanging in the balance. LINK

Politico's Darren Samuelsohn and Scott Wong: " Sequestration: Excuses, excuses, excuses" President Barack Obama and members of Congress have dubbed sequestration "stupid," "dumb" and "irresponsible." But here's one thing none of them are calling it: "My fault." With across-the-board spending cuts about to start March 1 absent a last-minute breakthrough, the excuses are piling up for how the country is yet again on the brink of a new fiscal fiasco that has everything to do with the other guy. LINK

PRESIDENT OBAMA AND HIS ADMINISTRATION The New York Daily News' Dan Hirschhorn: " Jimmy Carter says President Obama 'profusely' thanked his grandson following release of Mitt Romney's '47 percent' footage" Mitt Romney's presidential campaign may never have sunk the way it did were it not for the disclosure of his notorious "47 percent" comments - and President Obama is apparently quite grateful for the opposition researcher who helped unearth the video. Former President Jimmy Carter, whose grandson James helped bring the video to light, says Obama thanks James Carter "profusely" when the two met last week. LINK

The Hill's Jeremy Herb: " Inhofe pushes against proceeding to final up-or-down vote on Hagel" The top Republican on the Senate Armed Services Committee is calling for Republican senators to block former Sen. Chuck Hagel's (R-Neb.) confirmation once again when the Senate returns next week. Sen. James Inhofe (R-Okla.) sent a "Dear Colleague" letter to senators Thursday lobbying for them to vote against cloture on Hagel, saying that voting to end debate is the equivalent of voting to confirm Hagel for the top Pentagon post. LINK

AFGHANISTAN The Los Angeles Times' Shashank Bengali and David S. Cloud: " U.S. drone strikes up sharply in Afghanistan" One morning recently, a teenager named Bacha Zarina was collecting firewood on her family's small farm in eastern Afghanistan. About 30 yards away, as family members recall, two Taliban commanders stood outside a house. LINK

IMMIGRATION Univision/ABC News' Ted Hesson: " Business And Labor Reach An Agreement On Future Immigration" Business and labor leaders have come to an agreement in principle about one of the thorniest parts of immigration reform - what to do with future flows of immigrant workers. LINK

ABC NEWS VIDEO " Will Sequestration Turn US Into 'Second-Rate Power'" LINK " Biden Urges Stricter Gun Laws At Connecticut Conference" LINK

BOOKMARKS The Note: LINK The Must-Reads Online: LINK Top Line Webcast (12noon EST M-F): LINK ABC News Politics: LINK George's Bottom Line (George Stephanopoulos): LINK Follow ABC News on Twitter: LINK ABC News Mobile: LINK ABC News app on your iPhone/iPod Touch/iPad: LINK

Also Read

Source: http://news.yahoo.com/notes-must-reads-friday-february-22-2013-080030608--abc-news-politics.html

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Two Decades of Work, Challenges Behind Breakthrough Cancer ...

AAMC Reporter: January 2013
?By Sarah Mann

A new cancer therapy that genetically modifies patients? T cells to attack cancer cells could be a game changer for cancer patients. So far, researchers have used the therapy to treat 11 leukemia patients, whose only remaining treatment option was a bone marrow transplant. Researchers are hesitant to say they have developed a cure, but it could be a turning point.

?For the field this has been a paradigm shift,? said David Porter, M.D., a professor of medicine at the University of Pennsylvania Perelman School of Medicine, director of blood and bone marrow transplants at Penn?s Abramson Cancer Center, and co-principal investigator. ?This highlighted the fact that we are in an age where we can genetically modify cells and treat cancer. I think most people would agree that it?s realistic and should be studied rapidly whereas before there was much less interest.?

The findings are the first successful, sustained gene therapy that uses the body?s own immune cells to target cancer cells. In the research, detailed in the New England Journal of Medicine and Science Translational Medicine in 2011, T cells from leukemia patients were removed in a process similar to blood transfusion. Carl June, M.D., the lead investigator, and his research team then used a gene modification technique to encode the T cells with an antibody-like protein called a chimeric antigen receptor (CAR) that is designed to focus on cells that express CD19, which includes cancer cells and normal B cells. The modified cells were then put back into the patient?s body following chemotherapy. In addition to targeting the cancer cells, the CAR triggers other T cells to multiply?building an army of cells until all tumor cells are destroyed. The first patient who was treated with the therapy in July 2010 remains healthy.

According to June, a professor of immunotherapy at the Perelman school and director of translational research at the Abramson Cancer Center, a new therapy advancing from the bench to bedside without support from the pharmaceutical industry is unusual.

?This came out of an academic center; it was not done by the pharmaceutical industry,? June said, adding, ?It?s the first thing I know of to go that far without pharmaceutical involvement.? Last August, June and the team began working with the pharmaceutical company Novartis to scale up the treatment.

Behind the promising findings is a 20-year journey in research that included plenty of setbacks.

?When a breakthrough like [this] is announced, I?m reminded of the sudden fame of a new pop star with a breakout album,? said Louis J. DeGennaro, Ph.D., chief mission officer of the Leukemia & Lymphoma Society (LLS). ?When one ultimately digs into the new singer?s background, they have invariably been working at their craft for decades.?

June began research in gene therapy through ?serendipity.? Two decades ago, he was in the Navy, researching gene therapy as a possible treatment for HIV. He found that HIV patients who were treated with T cells that had been genetically engineered with CAR were healthy up to 11 years after receiving the initial therapy. Years later, when the cancer field began to look at gene therapy, June had a head start.

?It was fortuitous that I was in both fields and was able to take what I had learned in our HIV gene therapy trials and then apply that to cancer,? he said.

Funding, especially, was a major obstacle. Grants from the National Institutes of Health covered initial laboratory experiments but not clinical trials in patients. June had to apply for grants from foundations or philanthropists to fund trials.

?I had to be patient and stubborn. It was a lot easier just to do the experiments in the laboratory and not do the clinical trial,? June said.

LLS began funding June?s research in 1998, ultimately investing $21 million. The Alliance for Cancer Gene Therapy (ACGT) also funded a portion of the research.

In 2006, four years before the first patient was treated, June and Porter began creating the draft for the clinical trial. At first there was enough material to treat only three patients. It took another year to secure funding to manufacture enough material to treat additional patients, according to Porter.

?Once we had the suggestion that this was effective, the challenge was completely the opposite,? said Porter, a professor of medicine at the Perelman school and director of blood and bone marrow transplants at Penn?s Abramson Cancer Center. ?How do we manage all the patients who are potentially interested?? He added that the research team received about 3,000 e-mails in one month from interested patients. ?It was very difficult from a clinical standpoint, being a physician, getting so many inquiries for something that a patient, either rightly or wrongly, is convinced is their only hope and then having limited ability to treat them.?

Beginning this month, June and his team will start a phase two clinical trial to determine the optimal dose for the treatment. ?Right now, what we found is that one dose is safe, and we have a high response rate, so we?ll get experience with more patients,? June said.

Next, June hopes to translate the therapy to other cancers. ?The goal over the next five years is to determine how to adapt this to other cancers?breast cancer, lung cancer, ovarian cancer. We have a number of things to do.?

Now that there have been positive results, it?s time to use those findings to educate the public about the need for sustained research funding and the potential benefit of gene therapy, according to June.

?We had no idea what caused cancer before, and now in most cases we do,? he said. ?The genetic events are different from cancer to cancer, so now is not the time to pull back on the research. Now is when the public really is going to see the benefits.?

Barbara Netter, president and co-founder of ACGT, noted that the research should continue ?until we absolutely can say there is a cure. Now that there is some proof of concept, we need to move ourselves over that line until the point where we really feel sure there is a cure.?

Source: http://non-hodgkins-lymphoma.supportgroups.com/sg/non-hodgkins-lymphoma/two-decades-of-work-ch

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Friday, February 22, 2013

Eight questions about the Clippers as the NBA playoffs get closer

The Clippers are in the championship conversation.

Imagine saying that.

But it's true.

The Clippers have the third-best record in the Western Conference at 39-17, 4 1/2 games behind conference leader San Antonio (43-12) and 11/2 games behind Oklahoma City (39-14).

The Clippers have the best point guard in the NBA in Chris Paul and a rising star in power forward Blake Griffin.

They have the veteran presence of Chauncey Billups and the deepest team in the NBA, led by reserve guard Jamal Crawford.

So with 26 regular-season games left for the Clippers, it's time for them to make their push toward the playoffs.

Here are eight questions we need to answer about the Clippers:

How important is Chris Paul to the Clippers' championship hopes?

Really, you asked that question?

We've already said Paul is the best point guard in the NBA. He's one of the best closers, best leaders, best tacticians and best players in the league. He'll be mentioned as one of the most-valuable-player candidates behind LeBron James and Kevin Durant. Paul was just named the MVP of the All-Star game, which showed how great he is. The Clippers were 6-6 when Paul didn't play because of a bruised right kneecap.

So, to use a cliche: As Chris Paul goes, so go the Clippers.

Should the Clippers stand pat or make a move?

That's a tough question.

It comes down to whether the Clippers want to gamble and go all in for the risk of hoping to win an NBA title right now with an aging player like Kevin Garnett (36) or stand pat and try to win in the future with DeAndre Jordan (24) and Eric Bledsoe (23).

Clippers Coach Vinny Del Negro is in the last year of his contract and would like to push the envelope and go for it this season.

The Clippers' front office has to eye the future of the franchise and do what's best strategically and financially.

Garnett, who has been rumored to be in a deal between the Clippers and Celtics, would make L.A. better but also older and slower. Though Garnett has toughness and championship experience, he doesn't provide the athleticism, speed and youth that Jordan and Bledsoe give the Clippers. And that's what separates the Clippers from most teams.

If it were up to me, I'd stand pat. Here's why: The Clippers always talk about the process, the steps it takes to become a contender. Consider a young team like Oklahoma City. The Thunder lost to the Lakers in the first round of the 2010 playoffs, lost to the Dallas Mavericks in the 2011 Western Conference finals and then reached the NBA Finals in 2012 but lost to Miami.

Source: http://feeds.latimes.com/~r/latimes/sports/basketball/nba/~3/lThDREiH6OY/la-sp-clippers-questions-20130221,0,7558654.story

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MAAC basketball championships and Jimmy Fund team up to fight cancer


SPRINGFIELD ? Basketball fans who buy tickets to the Metro Atlantic Athletic Conference Championships will also be supporting a good cause.

The MAAC, which returns its men?s and women?s basketball championships to the MassMutual Center March 7-11, have partnered with The Jimmy Fund to support Dana-Farber Cancer Institute and the fight against cancer.

?The ticket includes a donation to The Jimmy Fund, it?s either one or two dollars depending on the price of the ticket and we do have tickets as low as $10,? MAAC commissioner Rich Ensor said Wednesday at a press conference held at the Naismith Memorial Basketball Hall of Fame. ?You can both support the charitable giving element tied into the ticket but also enjoy first-class Division I basketball here in Springfield.?

Hall of Fame vice president of finance and operations Don Senecal played a role in bringing the two organizations together.

Drawing from personal experience with Dana-Farber, having a close family member dealing with cancer and being blown away by the care and support offered up by Dana-Farber, Senecal decided to get more involved and bring his two worlds together.

?As a result of that, with the family experience, you didn?t have to sit back and prod me anymore, I said I?ve got to give back,? Senecal said. ?I?ve been on the (Western Massachusetts Jimmy Fund) council for a while and with my world of basketball and work with the MAAC through our partnership, I thought the Jimmy Fund could use something in basketball.

?The MAAC guys were outside the New England area but I brought them together to see if there was a symbiotic relationship and as a result there is an expansion of the market for the Jimmy Fund and for Rich it allows his student-athletes to participate,? Senecal said. ?It all sort of had the right chemistry to come together and I was happy to be a part of it.?

Besides the charitable contribution tied to the ticket price, the MAAC will be involved with the Jimmy Fund by running a ?text-to-give? campaign in which fans can text ?JIMMY? to 22122 which will donate $5 to the Jimmy Fund.

Also, MAAC student-athletes like Siena College volleyball player Elizabeth Ives and Fairfield rower Lorena Gullotta, who attended the press conference, will use a large Jimmy Fund canister at the MassMutual Center to collect donations during the championship.

?It?s personal now and I do believe in what the Jimmy Fund is doing,? Senecal said. ?They are going for a cure. These people are committed to a cure. This is an amazing organization and I truly believe this is something that can be cured and I?m committed to it.?

Source: http://www.masslive.com/sports/index.ssf/2013/02/maac_basketball_championships.html

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